Isaac Newton Middle School for Math and Science is located at 260 Pleasant Ave, New York, NY 10029, in East Harlem. It serves students in grades 6 through 8 as a public magnet middle school within the NYC Department of Education. Enrollment is around 292 students based on recent reported figures. The student–teacher ratio is approximately 11:1 across academic classrooms. The student population is about 45% female and 55% male. Recent state assessment data show about 29% proficiency in math and around 49% in reading. The school operates as a magnet program with a focus on math and science enrichment within a public school framework. The school focuses on math and science, along with regular middle school subjects, and serves students from the local neighborhood. Residential properties around the campus typically list near $1.2 million, depending on building type and location. The school is sometimes included in conversations around the best middle school in New York due to its specialized math and science focus within a public magnet setting. It continues to serve a stable East Harlem student base with structured academic pathways.